Comparison of in vitro methods of measuring mucoadhesion: Ellipsometry, tensile strength and rheological measurements.
Författare
Summary, in English
In this work three in vitro methods for the measurement of mucoadhesion have been compared: ellipsometry, tensile strength and rheology. The conditions used for the three methods have been as similar as possible. Six different polymers were investigated: sodium carboxymethyl cellulose (CMC), hydroxyethyl cellulose (HEC), chitosan, polyvinyl pyrrolidone (PVP) and two cross-linked polyacrylic acids, Noveon (hydrophobically modified) and Carbopol. The results showed that PVP did not exhibit mucoadhesion according to any of the methods used. Chitosan, Noveon, Carbopol, CMC and HEC showed good mucoadhesion in the tensile strength and the rheological measurements, but not in the ellipsometry investigation. Chitosan was the only polymer showing good mucoadhesion with the ellipsometry method. No two methods gave the same ranking of mucoadhesive strength of the polymers. The conflicting results obtained with the different methods underline the need for further improvements in existing experimental techniques and theoretical concepts for the correct assessment of mucoadhesive properties.
Avdelning/ar
- Department of Food Technology, Engineering and Nutrition
Publiceringsår
2012
Språk
Engelska
Sidor
353-359
Publikation/Tidskrift/Serie
Colloids and Surfaces. B, Biointerfaces
Volym
92
Länkar
Dokumenttyp
Artikel i tidskrift
Förlag
Elsevier
Ämne
- Physical Chemistry
Status
Published
ISBN/ISSN/Övrigt
- ISSN: 1873-4367