Dyskinesias following neural transplantation in Parkinson's disease.
Författare
Summary, in English
Severe dyskinesias during the 'off' phases (periods of increased Parkinson's disease (PD) disability) have been observed following intrastriatal transplantation of human embryonic mesencephalic tissue. Here we retrospectively analyzed 14 patients who were followed for up to 11 years after grafting, and found that dyskinesias (abnormal involuntary movements and postures) increased during postoperative off phases, but were generally of mild to moderate severity. Dyskinesia severity was not related to the magnitude of graft-derived dopaminergic re-innervation, as judged by (18)F-labeled 6-L-fluorodopa (FD) positron emission tomography (PET), indicating that off-phase dyskinesias probably did not result from excessive growth of grafted dopaminergic neurons.
Avdelning/ar
- Institutionen för hälsovetenskaper
- Neurobiologi
- Institutionen för experimentell medicinsk vetenskap
- Neurokirurgi
- Neurologi, Lund
- Wallenberg Neuroscience Centre, Lund
Publiceringsår
2002
Språk
Engelska
Sidor
627-628
Publikation/Tidskrift/Serie
Nature Neuroscience
Volym
5
Issue
7
Fulltext
- Available as PDF - 77 kB
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Länkar
Dokumenttyp
Artikel i tidskrift
Förlag
Nature Publishing Group
Ämne
- Neurosciences
Nyckelord
- Parkinson Disease : therapy
- Parkinson Disease : radionuclide imaging
- Neurons : transplantation
- Middle Age
- Mesencephalon : transplantation
- Mesencephalon : embryology
- Mesencephalon : cytology
- Hyperkinesis : etiology
- Hyperkinesis : diagnosis
- Human
- Dystonia : etiology
- Dystonia : diagnosis
- Dyskinesias : etiology
- Dyskinesias : diagnosis
- Disease Progression
- Cultured
- Cells
- Brain Tissue Transplantation : adverse effects
- Cell Division : physiology
- Postoperative Complications : diagnosis
- Postoperative Complications : etiology
- Putamen : physiopathology
- Putamen : radionuclide imaging
- Retrospective Studies
- Support
- Non-U.S. Gov't
- Time Factors
Status
Published
Forskningsgrupp
- Neurobiology
ISBN/ISSN/Övrigt
- ISSN: 1546-1726