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Dyskinesias following neural transplantation in Parkinson's disease.

Författare

Summary, in English

Severe dyskinesias during the 'off' phases (periods of increased Parkinson's disease (PD) disability) have been observed following intrastriatal transplantation of human embryonic mesencephalic tissue. Here we retrospectively analyzed 14 patients who were followed for up to 11 years after grafting, and found that dyskinesias (abnormal involuntary movements and postures) increased during postoperative off phases, but were generally of mild to moderate severity. Dyskinesia severity was not related to the magnitude of graft-derived dopaminergic re-innervation, as judged by (18)F-labeled 6-L-fluorodopa (FD) positron emission tomography (PET), indicating that off-phase dyskinesias probably did not result from excessive growth of grafted dopaminergic neurons.

Publiceringsår

2002

Språk

Engelska

Sidor

627-628

Publikation/Tidskrift/Serie

Nature Neuroscience

Volym

5

Issue

7

Dokumenttyp

Artikel i tidskrift

Förlag

Nature Publishing Group

Ämne

  • Neurosciences

Nyckelord

  • Parkinson Disease : therapy
  • Parkinson Disease : radionuclide imaging
  • Neurons : transplantation
  • Middle Age
  • Mesencephalon : transplantation
  • Mesencephalon : embryology
  • Mesencephalon : cytology
  • Hyperkinesis : etiology
  • Hyperkinesis : diagnosis
  • Human
  • Dystonia : etiology
  • Dystonia : diagnosis
  • Dyskinesias : etiology
  • Dyskinesias : diagnosis
  • Disease Progression
  • Cultured
  • Cells
  • Brain Tissue Transplantation : adverse effects
  • Cell Division : physiology
  • Postoperative Complications : diagnosis
  • Postoperative Complications : etiology
  • Putamen : physiopathology
  • Putamen : radionuclide imaging
  • Retrospective Studies
  • Support
  • Non-U.S. Gov't
  • Time Factors

Status

Published

Forskningsgrupp

  • Neurobiology

ISBN/ISSN/Övrigt

  • ISSN: 1546-1726