Vitronectin in host pathogen interactions and antimicrobial therapeutic applications
Författare
Summary, in English
Vitronectin (Vn) is a multifunctional glycoprotein profusely present in serum and bound to epithelial cell surfaces. It plays an important role in cell migration, tissue repair and regulation of membrane attack complex (MAC) formation. In the last decade the role of Vn has been extensively investigated in eukaryotic signalling and cell migration leading to the possibility of developing novel anticancer drugs. In parallel, several studies have suggested that pathogens utilize Vn in invasion of the host. Here we review the properties of Vn and its role in host-pathogen interactions that might be a future target for therapeutic intervention.
Avdelning/ar
Publiceringsår
2011
Språk
Engelska
Sidor
973-980
Publikation/Tidskrift/Serie
Central European Journal of Biology
Volym
6
Issue
6
Fulltext
- Available as PDF - 345 kB
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Dokumenttyp
Artikel i tidskrift
Förlag
Versita
Ämne
- Microbiology in the medical area
Nyckelord
- Bacteria
- Complement system
- Extracellular matrix
- Innate immunity
- Integrins
- Vitronectin
Status
Published
Forskningsgrupp
- Clinical Microbiology, Malmö
ISBN/ISSN/Övrigt
- ISSN: 1895-104X