Dacrymenone and VM 3298-2 - New antibiotics with antibacterial and antifungal activity

Summary, in English

Two new antibiotic metabolites, dacrymenone (1) and VM 3298-2 (2), were isolated from fermentations of a Dacrymyces sp., and their structures were determined by spectroscopic techniques. Dacrymenone (1) is a new eremophilane sesquiterpenoid while VM 3298-2 (2) is a bis-enol ether between methyl pyruvate and 4,6-dihydroxycyclohexan-1,3-dione. Dacrymenone (1) shows weak antibacterial and antifungal activity while VM 3298-2 (2) exhibits cytotoxic and antifungal activities.

• Författare: V Mierau; T Anke; Olov Sterner
• Avdelning/ar: Centrum för analys och syntes
• Publiceringsår: 2003
• Språk: Engelska
• Sidor: 541-546
• Publikation/Tidskrift/Serie: Zeitschrift fuer Naturforschung. Section C: A Journal of Biosciences
• Volym: 58
• Issue: 7-8
• Länkar: http://www.znaturforsch.com/ac/v58c/s58c0541.pdf
• Dokumenttyp: Artikel i tidskrift
• Förlag: Verlag der Zeitschrift für Naturforschung
• Ämne: Organic Chemistry
• Nyckelord: antifungal antibiotic; eremophilanes; Dacrymyces
• Status: Published
• ISBN/ISSN/Övrigt: ISSN: 0939-5075