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Thermodynamics of α- and β-structure formation in proteins

Författare:
Publiceringsår: 2003
Språk: Engelska
Sidor: 1466-1473
Publikation/Tidskrift/Serie: Biophysical Journal
Volym: 85
Nummer: 3
Dokumenttyp: Artikel
Förlag: Biophysical Society

Sammanfattning

An atomic protein model with a minimalistic potential is developed and then tested on an α-helix and a β-hairpin, using exactly the same parameters for both peptides. We find that melting curves for these sequences to a good approximation can be described by a simple two-state model, with parameters that are in reasonable quantitative agreement with experimental data. Despite the apparent two-state character of the melting curves, the energy distributions are found to lack a clear bimodal shape, which is discussed in some detail. We also perform a Monte Carlo-based kinetic study and find, in accord with experimental data, that the α-helix forms faster than the β-hairpin.

Disputation

Nyckelord

  • Chemistry
  • Biology and Life Sciences
  • Physics and Astronomy

Övriga

Published
Yes
  • ISSN: 0006-3495
  • ISSN: 1542-0086

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