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Basal superoxide as a sex-specific immune constraint

In English

Författare

Summary, in English

There is increasing evidence that reactive oxygen species (ROS), a group of unstable and highly reactive chemical molecules, play a key role in regulating and maintaining life-history trade-offs. Upregulation of ROS in association with immune activation is costly because it may result in an imbalance between pro- and antioxidants and, hence, oxidative damage. Previous research aimed at quantifying this cost has mostly focused on changes in the pro-/antioxidant balance subsequent to an immune response. Here, we test the hypothesis that systemic ROS may constrain immune activation. We show that systemic, pre-challenge superoxide (SO) levels are negatively related to the strength of the subsequent immune response towards the mitogen phytohaemagglutinin in male, but not female painted dragon lizards (Ctenophorus pictus). We therefore suggest that systemic SO constrains immune activation in painted dragon males. We speculate that this may be due to sex-specific selection pressures on immune investment.

Publiceringsår

2011

Språk

Engelska

Sidor

906-908

Publikation/Tidskrift/Serie

Biology letters

Volym

7

Issue

6

Dokumenttyp

Artikel i tidskrift

Förlag

Royal Society Publishing

Ämne

  • Biological Sciences

Nyckelord

  • reactive oxygen species
  • immunity
  • Ctenophorus pictus
  • phytohaemagglutinin

Status

Published

Projekt

  • Immunoecology

Forskningsgrupp

  • Molecular Ecology and Evolution Lab

ISBN/ISSN/Övrigt

  • ISSN: 1744-9561