Mammography Screening-Factors affecting Tumour Stage and Outcome
Författare
Summary, in English
For the analyses on obesity, cases were retrieved from the Malmö Breast Cancer Database and screening status was defined according to randomization in the Malmö Mammographic Screening Trial. For studies on molecular characteristics and breast density, cases were retieved from the Malmö Diet and Cancer Study.
In women not invited to screening in the MMST (controls), there was a positive association between obesity and tumour stage. Obese MMST controls also had an increased risk of breast cancer death during follow-up, i.e. a poor survival. In women invited to screening, no association was seen between between obesity and stage or breast cancer death. The examined tumour markers could only explain a minor part of the survival difference between screening-detected vs. clinically-detected women. Breast density was associatd with increased breast cancer mortality regardless of detection mode.
To summarize, obese, as compared to normal weight women, not invited to screening, were diagnosed at a relatively late stage, and had higher breast cancer mortality. These differences were not seen in women invited to screening. Molecular tumour markers could only explain differences in survival according to screening status to a small extent. Breast density was associated with a worse breast cancer survival rate regardless of screening status.
Avdelning/ar
Publiceringsår
2012
Språk
Engelska
Publikation/Tidskrift/Serie
Lund University Faculty of Medicine Doctoral Dissertation Series
Volym
2012:77
Dokumenttyp
Doktorsavhandling
Förlag
Department of Clinical Sciences, Lund University
Ämne
- Clinical Medicine
Nyckelord
- Screening mammography
- obesity
- breast density. length bias
- breast cancer mortality
Status
Published
Forskningsgrupp
- Surgery
Handledare
ISBN/ISSN/Övrigt
- ISSN: 1652-8220
- ISBN: 978-91-87189-40-1
Försvarsdatum
12 oktober 2012
Försvarstid
09:00
Försvarsplats
Kvinnoklinikens aula, Jan Waldenströms gata 47, Ing 74, plan 3, SUS, Malmö.
Opponent
- Lars Holmberg (professor)