Du är här

Does variability in cognitive performance correlate with frontal brain volume?

Författare:
  • Martin Lövdén
  • Florian Schmiedek
  • Kristen M Kennedy
  • Karen M Rodrigue
  • Ulman Lindenberger
  • Naftali Raz
Publiceringsår: 2012
Språk: Engelska
Publikation/Tidskrift/Serie: NeuroImage
Nummer: Online 20 September 2012
Dokumenttyp: Artikel
Förlag: Elsevier

Sammanfattning

Little is known about the neural correlates of within-person variability in cognitive performance. We investigated associations between regional brain volumes and trial-to-trial, block-to-block, and day-to-day variability in choice-reaction time, and episodic and working memory accuracy. Healthy younger (n=25) and older (n=18) adults underwent 101 daily assessments of cognitive performance, and their regional brain volumes were measured manually on magnetic resonance images. Results showed that smaller prefrontal white matter volumes were associated with higher block-to-block variability in choice-reaction time performance, with a stronger association observed among older adults. Smaller volumes of the dorsolateral prefrontal cortex covaried with higher block-to-block variability in episodic memory (number-word pair) performance. This association was stronger for younger adults. The observed associations between variability and brain volume were not due to individual differences in mean performance. Trial-to-trial and day-to-day variability in cognitive performance were unrelated to regional brain volume. We thus report novel findings demonstrating that block-by-block variability in cognitive performance is associated with integrity of the prefrontal regions and that between-person differences in different measures of variability of cognitive performance reflect different age-related constellations of behavioral and neural antecedents.

Disputation

Nyckelord

  • Medicine and Health Sciences

Övriga

Published
Yes
  • ISSN: 1095-9572

Box 117, 221 00 LUND
Telefon 046-222 00 00 (växel)
Telefax 046-222 47 20
lu [at] lu [dot] se

 

Fakturaadress: Box 188, 221 00 LUND
Organisationsnummer: 202100-3211
Om webbplatsen