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Optimizing nanovial outlet designs for improved solid-phase extraction in the integrated selective enrichment target-ISET.

Publiceringsår: 2012
Språk: Engelska
Sidor: 3143-3150
Publikation/Tidskrift/Serie: Electrophoresis
Volym: 33
Nummer: 21
Dokumenttyp: Artikel
Förlag: Wiley-Blackwell Publishing

Sammanfattning

The integrated selective enrichment target is a microfluidic platform for SPE sample preparation with integrated nanocolumns, which simultaneously offers direct MALDI MS read-out. Here, we present a study on the importance of different nanocolumn outlet hole geometries and hole areas in relation to MS signal intensity and reproducibility. A design solution that provides the flow characteristics required for robust sample preparation using automated liquid handling is reported.

Disputation

Nyckelord

  • Technology and Engineering

Övriga

Published
Yes
  • ISSN: 1522-2683

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