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Does Allergen-specific Immunotherapy Induce Contact Allergy to Aluminium?

In English

Författare

Summary, in English

Persistent, itching nodules have been reported to appear at the injection site after allergen-specific immuno-therapy with aluminium-precipitated antigen extract, occasionally in conjunction with contact allergy to aluminium. This study aimed to quantify the development of contact allergy to aluminium during allergen-specific immunotherapy. A randomized, controlled, single-blind multicentre study of children and adults entering allergen-specific immunotherapy was performed using questionnaires and patch-testing. A total of 205 individuals completed the study. In the 3 study groups all subjects tested negative to aluminium before allergen-specific immunotherapy and 4 tested positive after therapy. In the control group 4 participants tested positive to aluminium. Six out of 8 who tested positive also had atopic dermatitis. Positive test results were found in 5/78 children and 3/127 adults. Allergen-specific immunotherapy was not shown to be a risk factor for contact allergy to aluminium. Among those who did develop aluminium allergy, children and those with atopic dermatitis were more highly represented.

Publiceringsår

2013

Språk

Engelska

Sidor

50-56

Publikation/Tidskrift/Serie

Acta Dermato-Venereologica

Volym

93

Dokumenttyp

Artikel i tidskrift

Förlag

Medical Journals Limited

Ämne

  • Dermatology and Venereal Diseases

Status

Published

Forskningsgrupp

  • Occupational and Environmental Dermatology

ISBN/ISSN/Övrigt

  • ISSN: 1651-2057