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Alternatively folded proteins with unexpected beneficial functions

In English

Författare

  • Soyoung Min
  • James Meehan
  • Louise M. Sullivan
  • Nial P. Harte
  • Yongjing Xie
  • Gavin P. Davey
  • Catharina Svanborg
  • Andre Brodkorb
  • Ken Mok

Summary, in English

HAMLET (human alpha-lactalbumin made lethal to tumour cells) and its related partially unfolded protein-fatty acid complexes are novel biomolecular nanoparticles that possess relatively selective cytotoxic activities towards tumour cells. One of the key characteristics is the requirement for the protein to be partially unfolded, hence endowing native proteins with additional functions in the alternatively folded states. Beginning with the history of its discovery and development, the cellular targets that appear to be strongly correlated with tumour cell death are introduced in the present article.

Publiceringsår

2012

Språk

Engelska

Sidor

746-751

Publikation/Tidskrift/Serie

Biochemical Society Transactions

Volym

40

Dokumenttyp

Artikel i tidskrift

Förlag

Biochemical Society

Ämne

  • Biochemistry and Molecular Biology

Nyckelord

  • alternatively folded protein
  • bovine alpha-lactalbumin made lethal to
  • tumour cells (BAMLET)
  • equine lysozyme with oleic acid (ELOA)
  • human
  • alpha-lactalbumin made lethal to tumour cells (HAMLET)
  • multimeric
  • alpha-lactalbumin (MAL).

Status

Published

ISBN/ISSN/Övrigt

  • ISSN: 0300-5127