Frequent intratype neutralization by plasma immunoglobulin A identified in HIV-2 infection.
Författare
Summary, in English
Human immunodeficiency virus type 2 (HIV-2) is less transmissible and less pathogenic compared to HIV-1 and, when matched for CD4+ T cell count, the plasma viral load in HIV-2 infected individuals is approximately one log lower than in HIV-1 infected individuals. The explanation for these observations is elusive, but differences in virus controlling immunity generated in the two infections may be contributing factors. In the present study, we investigated neutralization by immunoglobulin A (IgA), in parallel with IgG, purified from plasma of HIV-1, HIV-2 and HIV-1/HIV-2 dually (HIV-D)-infected individuals. Neutralization was analyzed against HIV-1 and HIV-2 isolates using a plaque reduction assay. In HIV-2 infection, intratype-specific neutralization by IgA was frequently detected, although at a lesser magnitude then the corresponding IgG neutralizing titers. In contrast, neutralization by IgA could rarely be demonstrated in HIV-1 infection despite similar plasma IgA levels in both infections. In addition, IgA and IgG of HIV-D plasma neutralized the HIV-2 isolate more potently than the HIV-1 isolate, suggesting that the difference between neutralizing activity of plasma IgA and IgG depends on the virus itself. Taken together, these findings suggest that both IgA and IgG adds to the potent intratype neutralizing activity detected in HIV-2 plasma, which may contribute to virus control in HIV-2 infection.
Avdelning/ar
Publiceringsår
2013
Språk
Engelska
Sidor
470-478
Publikation/Tidskrift/Serie
AIDS Research and Human Retroviruses
Volym
29
Issue
3
Fulltext
- Available as PDF - 763 kB
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Länkar
Dokumenttyp
Artikel i tidskrift
Förlag
Mary Ann Liebert, Inc.
Ämne
- Infectious Medicine
Status
Published
Forskningsgrupp
- Infectious Diseases Research Unit
- Clinical Virology, Malmö
ISBN/ISSN/Övrigt
- ISSN: 1931-8405