5-(2 '-oxoheptadecyl)-resorcinol and 5-(2 '-oxononadecyl)-resorcinol, cytotoxic metabolites from a wood-inhabiting basidiomycete
Författare
Summary, in English
5-(2'-oxoheptadecyl)-resorcinol (1) and 5-(2'-oxononadecyl)-resorcinol (2) were isolated from fermentations of an imperfect basidiomycete. The structures of the compounds were determined by spectroscopic techniques. Both compounds exhibit cytotoxic effects against the human colon tumor cell lines COLO-320, DLD-1 and HT-29 and the human promyeloid leukemia cell line HL-60, the human leukemia T cell JURKAT, the human hepatocellular carcinoma cell line HEP-G2 as well as the J774 mouse macrophage cell line. The compounds induce morphological and physiological differentiation of HL-60 cells into granulocytes, which subsequently die by apoptosis. Both compounds show no antibacterial and antifungal activity.
Avdelning/ar
Publiceringsår
2002
Språk
Engelska
Sidor
1004-1008
Publikation/Tidskrift/Serie
Zeitschrift fuer Naturforschung. Section C: A Journal of Biosciences
Volym
57
Issue
11-12
Länkar
Dokumenttyp
Artikel i tidskrift
Förlag
Verlag der Zeitschrift für Naturforschung
Ämne
- Organic Chemistry
Nyckelord
- 5-(2'-oxoheptadecyl)-resorcinol and 5-(2'-oxononadecyl)-resorcinol
- basidiomycete
- cytotoxic activities
Status
Published
ISBN/ISSN/Övrigt
- ISSN: 0939-5075