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Hemoglobin adducts as a measure of variations in exposure to acrylamide in food and comparison to questionnaire data

Författare

Summary, in English

Measurement of haemoglobin (Hb) adducts from acrylamide (AA) and its metabolite glycidamide (GA) is a possibility to improve the exposure assessment in epidemiological studies of AA intake from food. This study aims to clarify the reliability of Hb-adduct measurement from individual single samples for exposure assessment of dietary AA intake. The intra-individual variations of AA- and GA-adduct levels measured in blood samples collected over 20 months from 13 non-smokers were up to 2-fold and 4-fold, respectively. The corresponding interindividual variations observed between 68 non-smokers, with large differences in AA intake, were 6-fold and 8-fold, respectively. The intra-individual variation of the GA-to-AA-adduct level ratio was up to 3-fold, compared to 11-fold between individuals (n = 68). From AA-adduct levels the average AA daily intake (n = 68) was calculated and compared to that estimated from dietary history methodology: 0.52 and 0.67 mu g/kg body weight and day, respectively. At an individual level the measures showed low association (Rs = 0.39). Conclusions: Dietary AA is the dominating source to measured AA-adduct levels and corresponding inter- and intra-individual variations in non-smokers. Measurements from single individual samples are useful for calculation of average M intake and its variation in a cohort, and for identification of individuals only from extreme intake groups. (C) 2012 Elsevier Ltd. All rights reserved.

Publiceringsår

2012

Språk

Engelska

Sidor

2531-2539

Publikation/Tidskrift/Serie

Food and Chemical Toxicology

Volym

50

Issue

7

Dokumenttyp

Artikel i tidskrift

Förlag

Elsevier

Ämne

  • Pharmacology and Toxicology

Nyckelord

  • Acrylamide
  • Dietary intake
  • Glycidamide
  • Dietary history methodology
  • Individual variation
  • Food frequency questionnaire

Status

Published

Forskningsgrupp

  • Nutrition Epidemiology

ISBN/ISSN/Övrigt

  • ISSN: 0278-6915