NF-kappa B signalling is attenuated by the E7 protein from cutaneous human papillomaviruses

Summary, in English

The high-risk Alpha-types of human papillomavirus (HPV) are the causative agent of cervical cancer, which is the second major cause of death among women worldwide. Recent investigations have shown that E7 from the Alpha-papillomavirus HPV-16 interacts with IKK alpha and IKK beta of the IKK complex in the NF-kappa B pathway leading to an attenuation of the activity. There is a possible link between development of non-melanoma skin cancer and cutaneous Beta-papillomavirus but if these HPV types attenuate the NF-kappa B pathway is unclear. Seven different E7 proteins, representing four out of the five different species of the Beta genus (HPV-20, -37, -38, -92, -93 and -96) and one from the Gamma genus (HPV-4) were investigated for potential modulation of the NF-kappa B pathway in U2OS cells. Our results demonstrate that E7 from all the cutaneous HPV types were capable of inhibiting the NF-kappa B activity as well as E7 from HPV-16. In addition, E7 proteins from the cutaneous HPV types demonstrated interaction with IKK alpha but not with IKK beta. The deregulation of the NF-kappa B pathway by cutaneous HPVs might contribute to the pathogenesis of non-melanoma skin cancers and its precursors. (C) 2012 Elsevier B.V. All rights reserved.

• Författare: Luise M. Byg; Jessica Vidlund; Natasa Vasiljevic; Dorte Clausen; Ola Forslund; Bodil Norrild
• Avdelning/ar: Klinisk mikrobiologi, Malmö; BioCARE: Biomarkers in Cancer Medicine improving Health Care, Education and Innovation
• Publiceringsår: 2012
• Språk: Engelska
• Sidor: 48-53
• Publikation/Tidskrift/Serie: Virus Research
• Volym: 169
• Issue: 1
• Länkar: http://dx.doi.org/10.1016/j.virusres.2012.06.028
• Dokumenttyp: Artikel i tidskrift
• Förlag: Elsevier
• Ämne: Microbiology in the medical area
• Nyckelord: Cutaneous HPV; E7; IKKalpha; NF-kappaB
• Status: Published
• Forskningsgrupp: Clinical Microbiology, Malmö
• ISBN/ISSN/Övrigt: ISSN: 1872-7492