Genome-wide association study identifies a common variant in RAD51B associated with male breast cancer risk

Summary, in English

We conducted a genome-wide association study of male breast cancer comprising 823 cases and 2,795 controls of European ancestry, with validation in independent sample sets totaling 438 cases and 474 controls. A SNP in RAD51B at 14q24.1 was significantly associated with male breast cancer risk (P = 3.02 x 10(-13); odds ratio (OR) = 1.57). We also refine association at 16q12.1 to a SNP within TOX3 (P = 3.87 x 10(-15); OR = 1.50).

• Författare: Nick Orr; Alina Lemnrau; Rosie Cooke; Olivia Fletcher; Katarzyna Tomczyk; Michael Jones; Nichola Johnson; Christopher J. Lord; Costas Mitsopoulos; Marketa Zvelebil; Simon S. McDade; Gemma Buck; Christine Blancher; Alison H. Trainer; Paul A. James; Stig E. Bojesen; Susanne Bokmand; Heli Nevanlinna; Johanna Mattson; Eitan Friedman; Yael Laitman; Domenico Palli; Giovanna Masala; Ines Zanna; Laura Ottini; Giuseppe Giannini; Antoinette Hollestelle; Ans M. W. van den Ouweland; Srdjan Novakovic; Mateja Krajc; Manuela Gago-Dominguez; Jose Esteban Castelao; Håkan Olsson; Ingrid Hedenfalk; Douglas F. Easton; Paul D. P. Pharoah; Alison M. Dunning; D. Timothy Bishop; Susan L. Neuhausen; Linda Steele; Richard S. Houlston; Montserrat Garcia-Closas; Alan Ashworth; Anthony J. Swerdlow
• Avdelning/ar: Bröstcancer-genetik; Bröst- och ovarialcancer; EpiHealth: Epidemiology for Health; BioCARE: Biomarkers in Cancer Medicine improving Health Care, Education and Innovation
• Publiceringsår: 2012
• Språk: Engelska
• Sidor: 1182-1184
• Publikation/Tidskrift/Serie: Nature Genetics
• Volym: 44
• Issue: 11
• Länkar: http://dx.doi.org/10.1038/ng.2417
• Dokumenttyp: Artikel i tidskrift
• Förlag: Nature Publishing Group
• Ämne: Cancer and Oncology
• Status: Published
• Forskningsgrupp: Breast and Ovarian Cancer Genomics
• ISBN/ISSN/Övrigt: ISSN: 1546-1718