Screening of yeast species for the stereo-selective reduction of bicyclo[2.2.2]octane-2,6-dione
Författare
Summary, in English
Yeast strains from more than 31 different genera were screened for the enantioselective reduction of bicyclo[2.2.2]-octane-2,6-dione (1). Reducing activity was found in 80% of the screened yeasts. Bicyclo[2.2.2]octane-2,6-dione was enantioselectively reduced (> 98% ee) to (1R, 4S, 6S)-6-hydroxybicyclo[2.2.2]octane-2-one (-)-2 by 69% of the strains. Enantioselective reduction of the diketone to (1S, 4R, 6S)-6-hydroxybicyclo[2.2.2]octane-2-one ((+)-3, >98% ee) as a major product is reported for the first time. Candida tropicalis UOFS Y-0534 and Candida wickerhamii UOFS Y-0652 displayed this unusual diastereoselectivity.
Publiceringsår
2002
Språk
Engelska
Sidor
1111-1114
Publikation/Tidskrift/Serie
Journal of the Chemical Society - Perkin Transactions 1
Issue
8
Dokumenttyp
Artikel i tidskrift
Förlag
Royal Society of Chemistry
Ämne
- Organic Chemistry
- Industrial Biotechnology
Status
Published
ISBN/ISSN/Övrigt
- ISSN: 1472-7781