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A variation in 3 ' UTR of hPTP1B increases specific gene expression and associates with insulin resistance

In English

Författare

  • R Di Paola
  • L Frittitta
  • G Miscio
  • M Bozzali
  • R Baratta
  • M Centra
  • D Spampinato
  • MG Santagati
  • T Ercolino
  • C Cisternino
  • T Soccio
  • S Mastroianno
  • V Tassi
  • Peter Almgren
  • A Pizzuti
  • R Vigneri
  • V Trischitta
Visa allt

Summary, in English

Protein tyrosine phosphatase 1B (PTP1B) inhibits insulin signaling and, when overexpressed, plays a role in insulin resistance (Ahmad et al. 1997). We identified, in the 3' untranslated region of the PTP1B gene, a 1484insG variation that, in two different populations, is associated with several features of insulin resistance: among male individuals, higher values of the insulin resistance HOMA(IR) index (P = .006), serum triglycerides (P = .0002), and total/HDL cholesterol ratio (P = .025) and, among female individuals, higher blood pressure (P = .01). Similar data were also obtained in a family-based association study by use of sib pairs discordant for genotype (Gu et al. 2000). Subjects carrying the 1484insG variant showed also PTP1B mRNA overexpression in skeletal muscle (6,166 +/- 1,879 copies/40 ng RNA vs. 2,983 +/- 1,620;). Finally, PTP1B mRNA stability was significantly higher (P < .01) in human embryo kidney 293 cells transfected with 1484insG PTP1B, as compared with those transfected with wild-type PTP1B. Our data indicate that the 1484insG allele causes PTP1B overexpression and plays a role in insulin resistance. Therefore, individuals carrying the 1484insG variant might particularly benefit from PTP1B inhibitors, a promising new tool for treatment of insulin resistance (Kennedy and Ramachandran 2000).

Publiceringsår

2002

Språk

Engelska

Sidor

806-812

Publikation/Tidskrift/Serie

American Journal of Human Genetics

Volym

70

Issue

3

Dokumenttyp

Artikel i tidskrift

Förlag

Cell Press

Ämne

  • Medical Genetics

Status

Published

Forskningsgrupp

  • Genomics, Diabetes and Endocrinology

ISBN/ISSN/Övrigt

  • ISSN: 0002-9297