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Inflammation and cholesterol

In English

Författare

Summary, in English

Atherosclerosis develops as a result of a chronic arterial inflammation and intimal Fibrosis. The disease represents in many respects a vascular repair process activated in response to injury caused by toxic breakdown products of aggregated and oxidized lipoproteins. The initial response of the artery involves expression of adhesion molecules and recruitment of leukocytes. Degenerated lipoproteins are removed front the extracellular space by macrophages. If lipoproteins continue to I process becomes chronic and accumulate. the inflammatory cytokines stimulate smooth muscle to migrate into the intima. These cells proliferate and form an atherosclerotic plaque. Plaque cell death and inflammation in response to oxidized lipids and other toxic factors May Cause plaques to rupture.

Publiceringsår

2002

Språk

Engelska

Sidor

18-25

Publikation/Tidskrift/Serie

European Heart Journal Supplements

Volym

4

Issue

Suppl A

Dokumenttyp

Artikel i tidskrift

Förlag

Oxford University Press

Ämne

  • Cardiac and Cardiovascular Systems

Nyckelord

  • lipoproteins
  • atherosclerosis
  • macrophages
  • immunity
  • smooth muscle
  • cells

Status

Published

Forskningsgrupp

  • Cardiovascular Research - Immunity and Atherosclerosis

ISBN/ISSN/Övrigt

  • ISSN: 1520-765X