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Inflammation and cholesterol

Författare:
Publiceringsår: 2002
Språk: Engelska
Sidor: A18-A25
Publikation/Tidskrift/Serie: European Heart Journal Supplements
Volym: 4
Nummer: Suppl A
Dokumenttyp: Artikel
Förlag: Oxford University Press

Sammanfattning

Atherosclerosis develops as a result of a chronic arterial inflammation and intimal Fibrosis. The disease represents in many respects a vascular repair process activated in response to injury caused by toxic breakdown products of aggregated and oxidized lipoproteins. The initial response of the artery involves expression of adhesion molecules and recruitment of leukocytes. Degenerated lipoproteins are removed front the extracellular space by macrophages. If lipoproteins continue to I process becomes chronic and accumulate. the inflammatory cytokines stimulate smooth muscle to migrate into the intima. These cells proliferate and form an atherosclerotic plaque. Plaque cell death and inflammation in response to oxidized lipids and other toxic factors May Cause plaques to rupture.

Disputation

Nyckelord

  • Medicine and Health Sciences
  • lipoproteins
  • atherosclerosis
  • macrophages
  • immunity
  • smooth muscle
  • cells

Övriga

Published
Yes
  • ISSN: 1520-765X

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