Combinations of cereal β-glucans and probiotics can enhance the anti-inflammatory activity on host cells by a synergistic effect

Summary, in English

The influence of oat and barley β-glucans on some features of diverse probiotic strains was investigated. Neither barley nor oat β-glucans supported the growth of any of the investigated strains when used as the sole carbon source in fermentation media. No protective effect by β-glucans was observed on bacterial survival to in vitro simulation of the human digestive tract. Moreover, the presence of β-glucans did not enhance the ability of probiotic bacteria to adhere on human intestinal cells. The immunomodulatory activities of probiotics, β-glucans, and their combinations were studied and compared in vitro by transcriptional analysis of immune-related genes on LPS-stimulated THP-1 macrophages. Immune modulating properties were evidenced. In particular, mixtures of probiotic microorganisms and barley β-glucans exhibited synergistic effects in modulating the transcriptional level of several immune-related genes, leading to an overall enhanced anti-inflammatory effect. Together, these findings suggest a promising application of probiotic bacteria and β-glucans in the preparation of dietary mixtures presenting health-promoting features such as immunomodulatory properties.

• Författare: Mattia Pia Arena; Pasquale Russo; Vittorio Capozzi; Ana Rascón; Giovanna E. Felis; Giuseppe Spano; Daniela Fiocco
• Avdelning/ar: Food for Health Science Centre
• Publiceringsår: 2016-05-01
• Språk: Engelska
• Sidor: 12-23
• Publikation/Tidskrift/Serie: Journal of Functional Foods
• Volym: 23
• Länkar: http://dx.doi.org/10.1016/j.jff.2016.02.015
• Dokumenttyp: Artikel i tidskrift
• Förlag: Elsevier
• Ämne: Food Science; Nutrition and Dietetics
• Nyckelord: Beta Glucan (PubChem CID: 9202437); Immune system; Prebiotics; Probiotics; Relative gene expression; Synbiotics; β-glucan
• Status: Published
• ISBN/ISSN/Övrigt: ISSN: 1756-4646