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A novel blood-based biomarker for detection of autism spectrum disorders.

In English

Författare

  • Momeni N
  • Bergquist J
  • Behnia F
  • Bengt Sivberg
  • Joghataei M. T.
  • Persson B. L.

Summary, in English

Autism spectrum disorders (ASD) are classified as neurological developmental disorders. Several studies have been carried out to find a candidate biomarker linked to the development of these disorders, but up to date no reliable biomarker is available. Mass spectrometry techniques have been used for protein profiling of blood plasma of children with such disorders in order to identify proteins/peptides that may be used as biomarkers for detection of the disorders. Three differentially expressed peptides with mass-charge (m/z) values of 2020 ± 1, 1864 ± 1 and 1978 ± 1 Da in the heparin plasma of children with ASD that were significantly changed as compared with the peptide pattern of the non-ASD control group are reported here. This novel set of biomarkers allows for a reliable blood-based diagnostic tool that may be used in diagnosis and potentially, in prognosis of ASD

Publiceringsår

2012

Språk

Engelska

Sidor

91-91

Publikation/Tidskrift/Serie

Translational Psychiatry

Volym

2

Issue

3

Dokumenttyp

Artikel i tidskrift

Förlag

Nature Publishing Group

Ämne

  • Health Sciences

Status

Published

Forskningsgrupp

  • Integrative Health Research

ISBN/ISSN/Övrigt

  • ISSN: 2158-3188