Blood perfusion studies on basal cell carcinomas in conjunction with photodynamic- and cryo therapy employing laser-Doppler imaging
Författare
Summary, in English
Superficial blood perfusion mas monitored using laser-Doppler perfusion imaging in connection with a phase LII clinical trial comparing photodynamic therapy, utilizing topically applied aminoleuvlinic acid, with cryotherapy of basal cell, carcinomas. A total of 526 images mere recorded before and immediately after the treatment and during the follow-up period. Before treatment, the lesions exhibited a blood perfusion 3+/-2 times that in normal tissue. Both treatment modalities induced an increased blood perfusion inside the lesions, which slowly approached normal values in conjunction with successful treatments. The blood perfusion in successfully treated lesions approached normal values 2 months after photodynamic therapy, and about 1 year after cryotherapy, The tissue perfusion in recurrent lesions did not decrease to normal values after the treatment, suggesting that the laser-Doppler perfusion imaging technique can be used to follow the healing process and discover possible persistent tumour growth.
Publiceringsår
2000
Språk
Engelska
Sidor
19-23
Publikation/Tidskrift/Serie
Acta Dermato-Venereologica
Volym
80
Issue
1
Länkar
Dokumenttyp
Artikel i tidskrift
Förlag
Medical Journals Limited
Ämne
- Dermatology and Venereal Diseases
Nyckelord
- laser-Doppler flowmetry
- aminolevulinic acid
- photochemotherapy
- basal cell
- carcinoma
- perfusion
- regional
Status
Published
ISBN/ISSN/Övrigt
- ISSN: 1651-2057