Peak Bone Mass, Lifestyle Factors and Birth Weight: A study of 25-year old women
Författare
Summary, in English
Aims: To evaluate peak bone mass and its association with birth weight, recreational levels of physical activity and smoking. To evaluate how bone mass in Swedish young adult women compares with other similarly aged populations and the DXA manufacturer supplied reference values.
Methods: 1061 women, aged 25 years at inclusion, were recruited to the PEAK-25 cohort. All participants were measured with DXA. In addition a comprehensive lifestyle questionnaire was completed, including detailed data on physical activities and smoking. Birth anthropometrics were obtained from the Swedish National Board of Health and Welfare.
Results: The BMD values of the PEAK-25 cohort were generally higher than equivalently aged European and North American cohorts and the reference cohort incorporated for reference in the DXA scanner. Women with lower birth weight had lower bone mineral content and lower birth weight appears to have a greater negative influence on bone mass than the positive influence of higher birth weight. Recreational levels of physical activity were found to be associated with higher peak bone mass and BMD gains were maximized through regular, high-impact exercise. We found that the quantity of cigarettes consumed, but not smoking duration, is negatively associated with peak bone mass. BMI increases with longer smoking duration and may partly reduce the adverse effects of smoking on bone.
Conclusions: If available, ethno-geographically obtained reference data should be used in order to receive more appropriate results from DXA scanning and improve diagnostic accuracy. We have identified risk factors associ-ated with peak bone mass which have the potential for modification. Promoting physical activity, even on recre-ational level, will have beneficial influence on peak bone mass. Further, if not complete cessation of smoking, a reduced number of cigarettes may have beneficial effects on bone health. For bone promoting measures, children with low birth weight ought to obtain additional support.
Publiceringsår
2013
Språk
Engelska
Publikation/Tidskrift/Serie
Lund University Faculty of Medicine Doctoral Dissertation Series
Volym
2013:32
Fulltext
Dokumenttyp
Doktorsavhandling
Förlag
Department of Clinical Sciences, Lund University
Ämne
- Clinical Medicine
Nyckelord
- Peak bone mass
- normative values
- birth weight
- physical activity
- smoking
- bone mineral density
- bone mineral content
- dual energy X-ray absorptiometry
Status
Published
Forskningsgrupp
- Orthopedics - Clinical and Molecular Osteoporosis Research
Handledare
- Kristina Åkesson
- Karl Obrant
- Fiona Mcguigan
ISBN/ISSN/Övrigt
- ISSN: 1652-8220
- ISBN: 978-91-87449-02-4
Försvarsdatum
12 april 2013
Försvarstid
09:00
Försvarsplats
Medicinska klinikens aula, Inga Marie Nilssons gata 46, SUS/Malmö
Opponent
- Peter Nordström (Professor)