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Staining-free malaria diagnostics by multispectral and multimodality light-emitting-diode microscopy.

In English

Författare

Summary, in English

We report an accurate optical differentiation technique between healthy and malaria-infected erythrocytes by quasi-simultaneous measurements of transmittance, reflectance, and scattering properties of unstained blood smears using a multispectral and multimode light-emitting diode microscope. We propose a technique for automated imaging, identification, and counting of malaria-infected erythrocytes for real-time and cost-effective parasitaemia diagnosis as an effective alternative to the manual screening of stained blood smears, now considered to be the gold standard in malaria diagnosis. We evaluate the performance of our algorithm against manual estimations of an expert and show a spectrally resolved increased scattering from malaria-infected blood cells.

Publiceringsår

2013

Språk

Engelska

Publikation/Tidskrift/Serie

Journal of Biomedical Optics

Volym

18

Issue

3

Dokumenttyp

Artikel i tidskrift

Förlag

SPIE

Ämne

  • Bioengineering Equipment

Status

Published

ISBN/ISSN/Övrigt

  • ISSN: 1083-3668