Accuracy of protein hydropathy predictions.
Författare
Summary, in English
Hydropathy is a dominant force in protein folding. Sequence-based hydropathy predictions are widely used, without knowledge about their accuracy and reliability. We investigated the prediction accuracy of 56 hydropathy scales by correlating predicted values with the accessible surface area in known protein structures. Results for different amino acids vary greatly within each scale. We also investigated prediction accuracies of amino acids separately in secondary structural elements and in protein fold families. Despite very low overall correlation, hydropathy predictions can still be used if the shape of the plot is important instead of the prediction values.
Publiceringsår
2010
Språk
Engelska
Sidor
735-754
Publikation/Tidskrift/Serie
International Journal of Data Mining and Bioinformatics
Volym
4
Issue
6
Länkar
Dokumenttyp
Artikel i tidskrift
Förlag
Inderscience Publishers
Ämne
- Medical Genetics
Nyckelord
- Computational Biology: methods
- Proteins: chemistry
- Proteins: metabolism
Status
Published
ISBN/ISSN/Övrigt
- ISSN: 1748-5673