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Copy number analysis indicates monoclonal origin of lethal metastatic prostate cancer.

In English

Författare

  • Wennuan Liu
  • Sari Laitinen
  • Sofia Khan
  • Mauno Vihinen
  • Jeanne Kowalski
  • Guoqiang Yu
  • Li Chen
  • Charles M Ewing
  • Mario A Eisenberger
  • Michael A Carducci
  • William G Nelson
  • Srinivasan Yegnasubramanian
  • Jun Luo
  • Yue Wang
  • Jianfeng Xu
  • William B Isaacs
  • Tapio Visakorpi
  • G Steven Bova
Visa allt

Summary, in English

Many studies have shown that primary prostate cancers are multifocal and are composed of multiple genetically distinct cancer cell clones. Whether or not multiclonal primary prostate cancers typically give rise to multiclonal or monoclonal prostate cancer metastases is largely unknown, although studies at single chromosomal loci are consistent with the latter case. Here we show through a high-resolution genome-wide single nucleotide polymorphism and copy number survey that most, if not all, metastatic prostate cancers have monoclonal origins and maintain a unique signature copy number pattern of the parent cancer cell while also accumulating a variable number of separate subclonally sustained changes. We find no relationship between anatomic site of metastasis and genomic copy number change pattern. Taken together with past animal and cytogenetic studies of metastasis and recent single-locus genetic data in prostate and other metastatic cancers, these data indicate that despite common genomic heterogeneity in primary cancers, most metastatic cancers arise from a single precursor cancer cell. This study establishes that genomic archeology of multiple anatomically separate metastatic cancers in individuals can be used to define the salient genomic features of a parent cancer clone of proven lethal metastatic phenotype.

Publiceringsår

2009

Språk

Engelska

Sidor

559-565

Publikation/Tidskrift/Serie

Nature Medicine

Volym

15

Issue

5

Dokumenttyp

Artikel i tidskrift

Förlag

Nature Publishing Group

Ämne

  • Medical Genetics

Nyckelord

  • DNA
  • Continental Population Groups: genetics
  • Pair 6: genetics
  • African Continental Ancestry Group: genetics
  • Pair 13: genetics
  • Human
  • Chromosomes
  • Neoplasm: genetics
  • Neoplasm Metastasis: genetics
  • Prostatic Neoplasms: genetics
  • Prostatic Neoplasms: mortality
  • Prostatic Neoplasms: pathology

Status

Published

ISBN/ISSN/Övrigt

  • ISSN: 1546-170X