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Classical conditioning of motor responses: What is the learning mechanism?

Författare

Summary, in English

According to a widely held assumption, the main mechanism underlying motor learning in the cerebellum, such as eyeblink conditioning, is long-term depression (LTD) of parallel fibre to Purkinje cell synapses. Here we review some recent physiological evidence from Purkinje cell recordings during conditioning with implications for models of conditioning. We argue that these data pose four major challenges to the LTD hypothesis of conditioning. (i) LTD cannot account for the pause in Purkinje cell firing that is believed to drive the conditioned blink. (ii) The temporal conditions conducive to LTD do not match those for eyeblink conditioning. (iii) LTD cannot readily account for the adaptive timing of the conditioned response. (iv) The data suggest that parallel fibre to Purkinje cell synapses are not depressed after learning a Purkinje cell CR. Models based on metabotropic glutamate receptors are also discussed and found to be incompatible with the recording data.

Publiceringsår

2013

Språk

Engelska

Sidor

81-87

Publikation/Tidskrift/Serie

Neural Networks

Volym

47

Issue

Mar,28

Dokumenttyp

Artikel i tidskrift

Förlag

Elsevier

Ämne

  • Basic Medicine
  • Neurosciences

Status

Published

Projekt

  • Thinking in Time: Cognition, Communication and Learning

Forskningsgrupp

  • Associative Learning

ISBN/ISSN/Övrigt

  • ISSN: 1879-2782