α-Synuclein: The Long Distance Runner.

Summary, in English

Parkinson's disease is characterized by α-synuclein pathology in the form of Lewy bodies and Lewy neurites. Braak et al described the spatial and temporal spread of α-synuclein pathology in Parkinson's disease. Recent experimental studies have demonstrated that α-synuclein can transfer from cell to cell. In this review, we highlight the involvement of α-synuclein in Parkinson's disease and in Braak's staging of Parkinson's disease pathology. We discuss whether a prion-like mechanism of α-synuclein spread might contribute to Parkinson's disease pathology. We describe recent studies investigating cell-to-cell transfer of α-synuclein and focus our review on the long-distance axonal transport of α-synuclein along neurons.

• Författare: Sonia George; Nolwen Rey; Nicole Reichenbach; Jennifer Steiner; Patrik Brundin
• Avdelning/ar: Institutionen för experimentell medicinsk vetenskap; MultiPark: Multidisciplinary research focused on Parkinson´s disease
• Publiceringsår: 2013
• Språk: Engelska
• Sidor: 350-357
• Publikation/Tidskrift/Serie: Brain Pathology
• Volym: 23
• Issue: 3
• Länkar: http://www.ncbi.nlm.nih.gov/pubmed/23587141?dopt=Abstract; http://dx.doi.org/10.1111/bpa.12046
• Dokumenttyp: Artikel i tidskrift
• Förlag: Wiley-Blackwell
• Ämne: Neurosciences
• Status: Published
• ISBN/ISSN/Övrigt: ISSN: 1750-3639