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Thymidine kinase diversity in bacteria

Publiceringsår: 2006
Språk: Engelska
Sidor: 1153-1158
Publikation/Tidskrift/Serie: Nucleosides, Nucleotides and Nucleic Acids
Volym: 25
Nummer: 9-11
Dokumenttyp: Artikel
Förlag: Taylor and Francis Ltd


Thymidine kinases (TKs) appear to be almost ubiquitous and are found in nearly all prokaryotes, eukaryotes, and several viruses. They are the key enzymes in thymidine salvage and activation of several anti-cancer and antiviral drugs. We show that bacterial TKs can be subdivided into 2 groups. The TKs from Gram-positive bacteria are more closely related to the eukaryotic TK1 enzymes than are TKs from Gram-negative bacteria.



  • Biology and Life Sciences
  • pyrimidines
  • nucleosides
  • thymidine kinase
  • deoxyribonucleoside kinase
  • evolution
  • nucleic acids precursors


  • ISSN: 1525-7770

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