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Thymidine kinase diversity in bacteria

Författare:
Publiceringsår: 2006
Språk: Engelska
Sidor: 1153-1158
Publikation/Tidskrift/Serie: Nucleosides, Nucleotides and Nucleic Acids
Volym: 25
Nummer: 9-11
Dokumenttyp: Artikel
Förlag: Taylor and Francis Ltd

Sammanfattning

Thymidine kinases (TKs) appear to be almost ubiquitous and are found in nearly all prokaryotes, eukaryotes, and several viruses. They are the key enzymes in thymidine salvage and activation of several anti-cancer and antiviral drugs. We show that bacterial TKs can be subdivided into 2 groups. The TKs from Gram-positive bacteria are more closely related to the eukaryotic TK1 enzymes than are TKs from Gram-negative bacteria.

Disputation

Nyckelord

  • Biology and Life Sciences
  • pyrimidines
  • nucleosides
  • thymidine kinase
  • deoxyribonucleoside kinase
  • evolution
  • nucleic acids precursors

Övriga

Published
Yes
  • ISSN: 1525-7770

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