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Thymidine kinases in archaea

  • Anders Ranegaard Clausen
  • A Matakos
  • Michael Sandrini
  • Jure Piskur (Professor)
Publiceringsår: 2006
Språk: Engelska
Sidor: 1159-1163
Publikation/Tidskrift/Serie: Nucleosides, Nucleotides and Nucleic Acids
Volym: 25
Nummer: 9-11
Dokumenttyp: Artikel
Förlag: Taylor and Francis Ltd


Twenty-six fully sequenced archaeal genomes were searched for genes coding for putative deoxyribonucleoside kinases (dNKs). We identified only 5 human-like thymidine kinase 1 genes (TK1s) and none for non-TK1 kinases. Four TK1s were identified in the Euryarchaea and one was found in the Crenarchaea, while none was found in Nanoarchaeum. The identified TK1s have high identity to Gram-positive bacteria TK1s. The TK1s from archaea, Gram-positive bacteria and eukaryotes share the same common ancestor, while the TK1s from Gram-negative bacteria belong to a less-related subgroup. It seems that a functional deoxyribonucleoside salvage pathway is not crucial for the archaeal cell.



  • Biology and Life Sciences
  • salvage pathway
  • thymidine kinase
  • deoxyribonucleosides kinase
  • evolution
  • archaea


  • ISSN: 1525-7770

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