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Thymidine kinases in archaea

In English

Författare

  • Anders Ranegaard Clausen
  • A Matakos
  • Michael Sandrini
  • Jure Piskur

Summary, in English

Twenty-six fully sequenced archaeal genomes were searched for genes coding for putative deoxyribonucleoside kinases (dNKs). We identified only 5 human-like thymidine kinase 1 genes (TK1s) and none for non-TK1 kinases. Four TK1s were identified in the Euryarchaea and one was found in the Crenarchaea, while none was found in Nanoarchaeum. The identified TK1s have high identity to Gram-positive bacteria TK1s. The TK1s from archaea, Gram-positive bacteria and eukaryotes share the same common ancestor, while the TK1s from Gram-negative bacteria belong to a less-related subgroup. It seems that a functional deoxyribonucleoside salvage pathway is not crucial for the archaeal cell.

Publiceringsår

2006

Språk

Engelska

Sidor

1159-1163

Publikation/Tidskrift/Serie

Nucleosides, Nucleotides & Nucleic Acids

Volym

25

Issue

9-11

Dokumenttyp

Artikel i tidskrift

Förlag

Taylor & Francis

Ämne

  • Biological Sciences

Nyckelord

  • salvage pathway
  • thymidine kinase
  • deoxyribonucleosides kinase
  • evolution
  • archaea

Status

Published

ISBN/ISSN/Övrigt

  • ISSN: 1525-7770