Meny

Javascript verkar inte påslaget? - Vissa delar av Lunds universitets webbplats fungerar inte optimalt utan javascript, kontrollera din webbläsares inställningar.
Du är här

Antigens for the selection of pan-variable number of tandem repeats motif-specific human antibodies against Mucin-1

Författare:
Publiceringsår: 2006
Språk: Engelska
Sidor: 116-124
Publikation/Tidskrift/Serie: Journal of Immunological Methods
Volym: 316
Nummer: 1-2
Dokumenttyp: Artikel
Förlag: Elsevier Science B.V.

Sammanfattning

Epitopes found on Mucin-1 are differentially expressed on tumour versus normal tissue. Such epitopes have also been shown to have a potential in immunotherapy and tumour detection. The major epitope explored in this context is located within the variable number of tandem repeats. It has however recently been demonstrated that this epitope exists in several sequence variants. The standard sequence is highly antigenic while the most common sequence variant is much less so. We have now explored routes employing defined synthetic antigens to ensure the development of human recombinant antibody specificities targeting both sequence variants of this epitope. These antibodies may serve as a platform for the development of human antibodies for efficient targeting of Mucin-1 in human disease. (c) 2006 Elsevier B.V. All rights reserved.

Disputation

Nyckelord

  • Medicine and Health Sciences
  • tumour-associated antigen
  • specificity
  • peptide
  • antigen
  • antibody
  • antibody library

Övriga

Published
Yes
  • ISSN: 0022-1759

Box 117, 221 00 LUND
Telefon 046-222 00 00 (växel)
Telefax 046-222 47 20
lu [at] lu [dot] se

Fakturaadress: Box 188, 221 00 LUND
Organisationsnummer: 202100-3211
Om webbplatsen