In vivo Sub-regional dGEMRIC Analysis and Contrast Distribution in Clinical Studies of Human Knee Cartilage
Författare
Summary, in English
Methods: Study I was a longitudinal study on 23 healthy volunteers; Study II was a case-control study on 9 sedentary individuals and 8 elite runners. Study III was a longitudinal study on 30 patients with a history of medial meniscectomy. They were divided into three groups according to self-reported changes in level of physical activity. MRI measurements were performed in femoral knee cartilage pre- & post-injection of Gd-DTPA2-. Depth-wise times p.i. depending on the study group.
Results: Studies I and II: before contrast injection, T1 was higher in the superficial region than in the deep regions of the cartilage. Bulk gadolinium concentration was negatively related to cartilage thickness. Gd-DTPA2- uptake was significantly slower in the deep region than in the superficial region of the cartilage. Gd concentration in the superficial region was independent of cartilage thickness. A trend was seen towards lower Gd concentration in the superficial layer of weight-bearing cartilage in elite runners, than in sedentary individuals. More contrast agent seen in superficial non-weight-bearing cartilage than weight-bearing cartilage. In Study III, those who increased their physical activity showed a significant increase in dGEMRIC index in both superficial and deep layers in lateral weight-bearing cartilage. Those who decreased their physical activity showed a significant decrease in dGEMRIC index in the medial weight-bearing cartilage.
Conclusions: The higher pre-contrast T1 in the superficial region than in the deep region is an indication of a higher water content in superficial cartilage. The uptake of contrast agent was found to be from the superficial region of the cartilage, with diffusion into the deeper parts, and this affects the interpretation of bulk dGEMRIC measurements. The Gd concentration in the superficial layer supports dGEMRIC findings that cartilage has an adaptive capacity to exercise, leading to increased glycosaminoglycan (GAG) content throughout the cartilage. Decreasing physical activity leads to a decrease in GAG content in the cartilage. Variation in cartilage thickness is a source of error in dGEMRIC that should be considered when analysing bulk values.
Avdelning/ar
- Joint and Soft Tissue Unit
Publiceringsår
2013
Språk
Engelska
Publikation/Tidskrift/Serie
Lund University Faculty of Medicine Doctoral Dissertation Series
Volym
2013:62
Fulltext
- Available as PDF - 827 kB
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Dokumenttyp
Doktorsavhandling
Förlag
Joint and Soft Tissue Unit
Ämne
- Orthopedics
Nyckelord
- MRI
- dGEMRIC
- sub-regional
- knee
- cartilage
- GAG
- meniscus injury
- osteoarthritis
- exercise.
Status
Published
Forskningsgrupp
- Joint and Soft Tissue Unit
Handledare
- Leif Dahlberg
- Carl Johan Tiderius
- Jonas Svensson
- Eveliina Lammentausta
ISBN/ISSN/Övrigt
- ISSN: 1652-8220
- ISBN: 978-91-87449-32-1
Försvarsdatum
10 juni 2013
Försvarstid
01:00
Försvarsplats
Lecture Hall, Department Of Orthopedics, Inga Marie Nilssons gata 22, 4th floor, Skane University Hospital, Malmo.
Opponent
- Fackson Mwale