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Compact archaeal variant of heme A synthase

Författare:
Publiceringsår: 2006
Språk: Engelska
Sidor: 5351-5356
Publikation/Tidskrift/Serie: FEBS Letters
Volym: 580
Nummer: 22
Dokumenttyp: Artikel
Förlag: Elsevier Science B.V.

Sammanfattning

The N- and C-terminal halves of the heme A synthase polypeptide of Bacillus subtilis, and many other organisms, are homologous. This indicates that these enzyme proteins originate from a tandem duplication and fusion event of a gene encoding a protein half as large. The ape1694 gene of the hyperthermophilic archaeon Aeropyrum pernix encodes a protein that is similar to the hypothetical small primordial protein. We demonstrate that this A. pernix protein is a heat-stable membrane bound heme A synthase designated cCtaA. The case of cCtaA is unusual in evolution in that the primordial-like protein has not become extinct and apparently carries out the same function as the twice as large more diversified heme A synthase protein variant found in most cytochrome a-containing organisms.

Disputation

Nyckelord

  • Biology and Life Sciences
  • Aeropyrum
  • protein evolution
  • ape1694
  • heme A synthesis
  • CtaA
  • cCtaA
  • pernix

Övriga

Published
Yes
  • ISSN: 0014-5793

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