Inhibition of nuclear factor of activated T-cells (NFAT) suppresses accelerated atherosclerosis in diabetic mice.
Författare
Summary, in English
Diabetic patients have a much more widespread and aggressive form of atherosclerosis and therefore, higher risk for myocardial infarction, peripheral vascular disease and stroke, but the molecular mechanisms leading to accelerated damage are still unclear. Recently, we showed that hyperglycemia activates the transcription factor NFAT in the arterial wall, inducing the expression of the pro-atherosclerotic protein osteopontin. Here we investigate whether NFAT activation may be a link between diabetes and atherogenesis.
Avdelning/ar
Publiceringsår
2013
Språk
Engelska
Publikation/Tidskrift/Serie
PLoS ONE
Volym
8
Issue
6
Fulltext
Länkar
Dokumenttyp
Artikel i tidskrift
Förlag
Public Library of Science (PLoS)
Ämne
- Cardiac and Cardiovascular Systems
- Clinical Medicine
- Endocrinology and Diabetes
Status
Published
Forskningsgrupp
- Cardiovascular Research - Immunity and Atherosclerosis
- Diabetic Complications
- Diabetes - Molecular Metabolism
ISBN/ISSN/Övrigt
- ISSN: 1932-6203