Cylindrocyclin A, a new cytotoxic cyclopeptide from Cylindrocarpon sp.

Summary, in English

In the course of a screening of fungal extracts for new metabolites with cytotoxic activities cylindrocyclin A (1) was isolated. The producing strain was identified as Cylindrocarpon sp. by microscopy and ITS rDNA sequence analysis. 1 is a novel compound that exhibits cytotoxic acticity against six different cell lines with IC50 values ranging from 11 to 53 mu M. 1 has no antibacterial or antifungal activity. The compound is a cyclic nonapeptide comprising three alanines, five leucines and one isoleucine. Four amino acids are N-methylated. Its structure was elucidated by spectroscopic methods.

• Författare: Daniela Weber; Gilda Erosa; Olov Sterner; Timm Anke
• Avdelning/ar: Centrum för analys och syntes
• Publiceringsår: 2006
• Språk: Engelska
• Sidor: 495-499
• Publikation/Tidskrift/Serie: Journal of Antibiotics
• Volym: 59
• Issue: 8
• Länkar: http://www.jstage.jst.go.jp/article/antibiotics/59/8/59_495/_article
• Dokumenttyp: Artikel i tidskrift
• Förlag: Japan Antibiotics Research Association
• Ämne: Organic Chemistry
• Nyckelord: cylindrocarpon; cytotoxic; new metabolite; cyclopeptide
• Status: Published
• ISBN/ISSN/Övrigt: ISSN: 0021-8820