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From starch to starch microspheres: Factors controlling the microspheres quality

In English

Författare

  • Lidia Elfstrand
  • Ann-Charlotte Eliasson
  • Monica Jönsson
  • Mats Reslow
  • Marie Wahlgren

Summary, in English

Starch microparticle is a dosage form suitable for encapsulation of protein drugs. The microparticle characteristics can be influential factors for consecutive sustained drug release from the starch matrix and impact its ability to be coated by poly(D,L-lactide-co-glycolide). In this study, six types of starch microparticles were investigated and characterized. Desired qualities of the microspheres such as spherical form of the particles, well-defined and sharp particle contours were coincident with coarse surface morphology, sharp and distinct peaks in DSC and X-ray graphs. It was concluded that the quality of the starch microparticles was influenced by molecular properties of the starch material as well as type of buffer, and these factors were related to recrystallization kinetics, amount and quality of ordered/crystalline structure of final starch microspheres and their microscopic appearance.

Avdelning/ar

Publiceringsår

2006

Språk

Engelska

Sidor

381-390

Publikation/Tidskrift/Serie

Stärke

Volym

58

Issue

8

Dokumenttyp

Artikel i tidskrift

Förlag

John Wiley & Sons Inc.

Ämne

  • Food Engineering

Nyckelord

  • quality
  • product
  • microscopic appearance
  • starch microspheres
  • crystallinity

Status

Published

ISBN/ISSN/Övrigt

  • ISSN: 0038-9056