Webbläsaren som du använder stöds inte av denna webbplats. Alla versioner av Internet Explorer stöds inte längre, av oss eller Microsoft (läs mer här: * https://www.microsoft.com/en-us/microsoft-365/windows/end-of-ie-support).

Var god och använd en modern webbläsare för att ta del av denna webbplats, som t.ex. nyaste versioner av Edge, Chrome, Firefox eller Safari osv.

Effect of systemic administration of nicotine on healing in osseous defects. An experimental study in rabbits. Part II

In English

Författare

  • Dimitra Balatsouka
  • Klaus Gotfredsen
  • Lars Sorensen
  • Christian Lindh
  • Tord Berglundh

Summary, in English

Objectives: The aim of the present study was to analyze the effect of systemic administration of nicotine on bone healing in osseous defects in the tibia of rabbits. Materials and methods: Sixteen female rabbits received nicotine (n=8; test group) or saline (n=8; control group) via subcutaneously placed mini-osmotic pumps for 8 weeks. The animals underwent three surgical operations during the experimental period, and body weight was registered weekly. Blood samples were collected to determine cotinine and prostaglandin E-2 levels. Bone preparations were made in the right leg of all rabbits after 4 weeks and in the left leg after 6 weeks of nicotine/placebo exposure. Thus, 2- and 4-week healing groups were created for the bone defects. After 8 weeks, the animals were killed. Tissue blocks including the bone defects were prepared for histological analysis. Results: The animals in the test group lost weight, while the control group gained weight during the experiment. The prostaglandin E-2 levels in plasma increased significantly following nicotine exposure in the test group. No significant differences in the percentage of vessels and bone density in the osseous defects were found between the test and the control groups after 2 and 4 weeks of healing. Conclusions: In this experiment, systemic administration of nicotine over 4 or 6 weeks, respectively, influenced body weight and systemic prostaglandin E-2 levels but not the amount of blood vessels and the bone mineral density in bone defects after 2 or 4 weeks of healing.

Publiceringsår

2006

Språk

Engelska

Sidor

488-494

Publikation/Tidskrift/Serie

Clinical Oral Implants Research

Volym

17

Issue

5

Dokumenttyp

Artikel i tidskrift

Förlag

Wiley-Blackwell

Ämne

  • Environmental Health and Occupational Health

Nyckelord

  • nicotine
  • body weight
  • bone healing
  • vessels
  • prostaglandin E-2

Status

Published

ISBN/ISSN/Övrigt

  • ISSN: 1600-0501