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Portal vein thrombosis: Prevalence, patient, characteristics and lifetime risk: A population study based on 23796 consecutive autopsies

Författare

  • Mats Ogren
  • David Bergqvist
  • Martin Bjorck
  • Stefan Acosta
  • Henry Eriksson
  • Nils Sternby

Summary, in English

AIM: To assess the lifetime cumulative incidence of portal venous thrombosis (PVT) in the general population. METHODS: Between 1970 and 1982, 23 796 autopsies, representing 84% of all in-hospital deaths in the Malmo city population, were performed, using a standardised protocol including examination of the portal vein. PVT patients were characterised and the PVT prevalence at autopsy, an expression of life-time cumulative incidence, assessed in high-risk disease categories and expressed in terms of odds ratios and 95% CI. RESULTS: The population prevalence of PVT was 1.0%. Of the 254 patients with PVT 28% had cirrhosis, 23% primary and 44% secondary hepatobiliary malignancy, 10% major abdominal infectious or inflammatory disease and 3% had a myeloproliferative disorder. Patients with both cirrhosis and hepatic carcinoma had the highest PVT risk, OR 17.1 (95% CI 11.1-26.4). In 14% no cause was found; only a minority of them had developed portal-hypertension-related complications. CONCLUSION: In this population-based study, PVT was found to be more common than indicated by previous clinical series. The markedly excess risk in cirrhosis and hepatic carcinoma should warrant an increased awareness in these patients for whom prospective studies of directed intervention might be considered. (C) 2006 The WJG Press. All rights reserved.

Publiceringsår

2006

Språk

Engelska

Sidor

2115-2119

Publikation/Tidskrift/Serie

World Journal of Gastroenterology

Volym

12

Issue

13

Dokumenttyp

Artikel i tidskrift

Förlag

WJG Press

Ämne

  • Gastroenterology and Hepatology

Nyckelord

  • portal hypertension
  • epidemiology
  • venous thrombosis
  • gastrointestinal cancer
  • cirrhosis

Status

Published

Forskningsgrupp

  • Pathology, Malmö

ISBN/ISSN/Övrigt

  • ISSN: 1007-9327