Detailed Analysis of Focal Chromosome Arm 1q and 6p Amplifications in Urothelial Carcinoma Reveals Complex Genomic Events on 1q, and SOX4 as a Possible Auxiliary Target on 6p.
Författare
Summary, in English
Urothelial carcinoma shows frequent amplifications at 6p22 and 1q21-24. The main target gene at 6p22 is believed to be E2F3, frequently co-amplified with CDKAL1 and SOX4. There are however reports on 6p22 amplifications that do not include E2F3. Previous analyses have identified frequent aberrations occurring at 1q21-24. However, due to complex rearrangements it has been difficult to identify specific 1q21-24 target regions and genes.
Avdelning/ar
- Bröstcancer-genetik
- Institutionen för translationell medicin
- Genomiska analyser av urinblåscancer
- BioCARE: Biomarkers in Cancer Medicine improving Health Care, Education and Innovation
Publiceringsår
2013
Språk
Engelska
Publikation/Tidskrift/Serie
PLoS ONE
Volym
8
Issue
6
Fulltext
Länkar
Dokumenttyp
Artikel i tidskrift
Förlag
Public Library of Science (PLoS)
Ämne
- Cancer and Oncology
Status
Published
Forskningsgrupp
- Urothelial Cancer Genomics
ISBN/ISSN/Övrigt
- ISSN: 1932-6203