Detailed Analysis of Focal Chromosome Arm 1q and 6p Amplifications in Urothelial Carcinoma Reveals Complex Genomic Events on 1q, and SOX4 as a Possible Auxiliary Target on 6p.

Summary, in English

Urothelial carcinoma shows frequent amplifications at 6p22 and 1q21-24. The main target gene at 6p22 is believed to be E2F3, frequently co-amplified with CDKAL1 and SOX4. There are however reports on 6p22 amplifications that do not include E2F3. Previous analyses have identified frequent aberrations occurring at 1q21-24. However, due to complex rearrangements it has been difficult to identify specific 1q21-24 target regions and genes.

• Författare: Pontus Eriksson; Mattias Aine; Gottfrid Sjödahl; Johan Staaf; David Lindgren; Mattias Höglund
• Avdelning/ar: Bröstcancer-genetik; Institutionen för translationell medicin; Genomiska analyser av urinblåscancer; BioCARE: Biomarkers in Cancer Medicine improving Health Care, Education and Innovation
• Publiceringsår: 2013
• Språk: Engelska
• Publikation/Tidskrift/Serie: PLoS ONE
• Volym: 8
• Issue: 6
• Fulltext: - 3 MB; Download statistics
• Länkar: http://www.ncbi.nlm.nih.gov/pubmed/23825644?dopt=Abstract; http://dx.doi.org/10.1371/journal.pone.0067222
• Dokumenttyp: Artikel i tidskrift
• Förlag: Public Library of Science (PLoS)
• Ämne: Cancer and Oncology
• Status: Published
• Forskningsgrupp: Urothelial Cancer Genomics
• ISBN/ISSN/Övrigt: ISSN: 1932-6203