Isolation and characterization of two verrucarins from Myrothecium roridum

Summary, in English

In the course of a screening for compounds inhibiting the growth of two human breast cancer cells lines, two highly cytotoxic compounds were isolated from fermentations of Myrothecium roridum. The elucidation of their structures revealed that they are macrocyclic trichothecenes of the verrucarin type, 16-hydroxyverrucarin A (1), reported here as a natural product for the first time, and verrucarin X (2), a new compound. Both 1 and 2 exhibit moderate antifungal activity and pronounced cytotoxic activity, with IC50 values in the nanomolar (1) and micromolar (2) range. Both compounds preferentially inhibit in vivo protein biosynthesis.

• Författare: Sylvia Schoettler; Marcelo Bascope; Olov Sterner; Timm Anke
• Avdelning/ar: Centrum för analys och syntes
• Publiceringsår: 2006
• Språk: Engelska
• Sidor: 309-314
• Publikation/Tidskrift/Serie: Zeitschrift fuer Naturforschung. Section C: A Journal of Biosciences
• Volym: 61
• Issue: 5-6
• Länkar: http://www.znaturforsch.com/ac/v61c/c61c.htm#No5
• Dokumenttyp: Artikel i tidskrift
• Förlag: Verlag der Zeitschrift für Naturforschung
• Ämne: Organic Chemistry
• Nyckelord: Myrothecium roridum; 16-hydroxyverrucarin A; verrucarin X; protein; synthesis inhibitors
• Status: Published
• ISBN/ISSN/Övrigt: ISSN: 0939-5075