Identification of Novel Spinal Cholinergic Genetic Subtypes Disclose Chodl and Pitx2 as Markers for Fast Motor Neurons and Partition Cells
Författare
Summary, in English
Spinal cholinergic neurons are critical for motor function in both the autonomic and somatic nervous systems and are affected in spinal cord injury and in diseases such as amyotrophic lateral sclerosis (ALS) and spinal muscular atrophy. Using two screening approaches and in situ hybridization, we identified 159 genes expressed in typical cholinergic patterns in the spinal cord. These include two general cholinergic neuron markers, one gene exclusively expressed in motor neurons, and nine genes expressed in unknown sub-types of somatic motor neurons. Further, we present evidence that chondrolectin (Chodl) is expressed by fast motor neurons and that estrogen-related receptor beta (ERR beta) is a candidate marker for slow motor neurons. In addition, we suggest paired-like homeodomain transcription factor 2 (Pitx2) as a marker for cholinergic partition cells. J. Comp. Neurol. 518:2284-2304, 2010. (C) 2010 Wiley-Liss, Inc.
Publiceringsår
2010
Språk
Engelska
Sidor
2284-2304
Publikation/Tidskrift/Serie
Journal of Comparative Neurology
Volym
518
Issue
12
Dokumenttyp
Artikel i tidskrift
Förlag
John Wiley & Sons Inc.
Ämne
- Neurology
Nyckelord
- cord
- spinal
- motor neuron
- interneuron
- mouse genetics
- neuronal network
- genetic screen
Status
Published
ISBN/ISSN/Övrigt
- ISSN: 1096-9861