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Mechanisms underlying cortical resonant states: implications for levodopa-induced dyskinesia

In English

Författare

Summary, in English

A common observation in recordings of neuronal activity from the cerebral cortex is that populations of neurons show patterns of synchronized oscillatory activity. However, it has been suggested that neuronal synchronization can, in certain pathological conditions, become excessive and possibly have a pathogenic role. In particular, aberrant oscillatory activation patterns have been implicated in conditions involving cortical dysfunction. We here review the mechanisms thought to be involved in the generation of cortical oscillations and discuss their relevance in relation to a recent finding indicating that high-frequency oscillations in the cerebral cortex have an important role in the generation of levodopa-induced dyskinesia. On the basis of these insights, it is suggested that the identification of physiological changes associated with symptoms of disease is a particularly important first step toward a more rapid development of novel treatment strategies.

Publiceringsår

2013

Språk

Engelska

Sidor

415-429

Publikation/Tidskrift/Serie

Reviews in the Neurosciences

Volym

24

Issue

4

Dokumenttyp

Artikel i tidskrift

Förlag

Freund Publishing House Ltd

Ämne

  • Neurosciences

Nyckelord

  • basal ganglia
  • dopamine
  • motor cortex
  • neuronal circuits
  • oscillations
  • Parkinson's disease

Status

Published

Forskningsgrupp

  • Integrative Neurophysiology
  • Neuronano Research Center (NRC)

ISBN/ISSN/Övrigt

  • ISSN: 0334-1763