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Genes and type 2 diabetes mellitus.

Författare

  • Leif Groop
  • Valeriya Lyssenko

Summary, in English

In 2007, five whole genome-wide association studies were published on the genetics of type 2 diabetes mellitus (T2DM), followed by the discovery of 11 genes consistently associated with T2DM. This breakthrough provided the first glimpses of a complete picture of the disease's genetic complexity. Currently, we are only beginning to understand how DNA methylation, histone acetylation, and deacetylation may introduce epigenetic changes throughout one's lifetime. Such changes may influence age-related modifications in gene-expression that contribute to age-related diseases. In the future, the possibility of whole-genome DNA methylation studies may elucidate the extent of these epigenetic effects. This article reviews genes that have recently been determined to be associated with T2DM.

Publiceringsår

2008

Språk

Engelska

Sidor

192-197

Publikation/Tidskrift/Serie

Current Diabetes Reports

Volym

8

Issue

3

Dokumenttyp

Artikel i tidskrift

Förlag

Current Science, Inc.

Ämne

  • Endocrinology and Diabetes

Status

Published

Forskningsgrupp

  • Genomics, Diabetes and Endocrinology

ISBN/ISSN/Övrigt

  • ISSN: 1539-0829