Total Synthesis of Transtaganolide E and F: Insight in the Biosynthesis of the Transtaganolides

Summary, in English

A total synthesis of transtaganolide E and F, proposed intermediates in the biosynthesis of the potent transtaganolides, including an Ireland-Claisen rearrangement and a high-pressure intramolecular Diels-Alder cycloaddition reaction of an unactivated 2-pyrone derivative, is reported. The implication of the results to the proposed transtaganolides biosynthesis is discussed.

• Författare: Rikard Larsson; Hans W. Scheeren; Rene W. M. Aben; Martin H Johansson; Olov Sterner
• Avdelning/ar: Centrum för analys och syntes
• Publiceringsår: 2013
• Språk: Engelska
• Sidor: 6955-6960
• Publikation/Tidskrift/Serie: European Journal of Organic Chemistry
• Volym: 2013
• Issue: 30
• Länkar: http://dx.doi.org/10.1002/ejoc.201301092
• Dokumenttyp: Artikel i tidskrift
• Förlag: John Wiley & Sons Inc.
• Ämne: Chemical Sciences
• Nyckelord: Transtaganolides; Rearrangement; Cycloaddition; Biosynthesis; Natural; products
• Status: Published
• ISBN/ISSN/Övrigt: ISSN: 1434-193X