The Heck reaction under ball-milling conditions

Summary, in English

The synthesis of unsaturated unnatural amino acids according to the Heck-Jeffery protocol using a ball-milling procedure is presented. NOE data recorded on the products confirm that the Z-isomer is formed. This type of mechano-chemistry provides an efficient, "solvent free" and reliable method for the synthesis of substituted dehydroalanines. These conditions provide patterns of reactivity complementary to conventional procedures. (C) 2004 Elsevier B.V. All rights reserved.

• Författare: Erik Tullberg; D Peters; Torbjörn Frejd
• Avdelning/ar: Centrum för analys och syntes
• Publiceringsår: 2004
• Språk: Engelska
• Sidor: 3778-3781
• Publikation/Tidskrift/Serie: Journal of Organometallic Chemistry
• Volym: 689
• Issue: 23
• Länkar: http://dx.doi.org/10.1016/j.jorganchem.2004.06.045
• Dokumenttyp: Artikel i tidskrift
• Förlag: Elsevier
• Ämne: Organic Chemistry
• Status: Published
• ISBN/ISSN/Övrigt: ISSN: 0022-328X