Identification of transcriptional subgroups in EGFR-mutated and EGFR/KRAS-wild type lung adenocarcinoma reveals gene signatures associated with patient outcome.
Författare
Summary, in English
In lung adenocarcinoma, EGFR and KRAS mutations dominate the mutational spectrum and have clear therapeutic implications. We sought to determine whether transcriptional subgroups of clinical relevance exist within EGFR-mutated, KRAS-mutated, or EGFR and KRAS-wild type (EGFRwt/KRASwt) adenocarcinomas.
Avdelning/ar
- Bröstcancer-genetik
- Forskningsgrupp Lungcancer
- BioCARE: Biomarkers in Cancer Medicine improving Health Care, Education and Innovation
Publiceringsår
2013
Språk
Engelska
Sidor
5116-5126
Publikation/Tidskrift/Serie
Clinical Cancer Research
Volym
19
Issue
18
Länkar
Dokumenttyp
Artikel i tidskrift
Förlag
American Association for Cancer Research
Ämne
- Cancer and Oncology
Status
Published
Forskningsgrupp
- Research Group Lung Cancer
ISBN/ISSN/Övrigt
- ISSN: 1078-0432