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Benchmark dose for cadmium-induced renal effects in humans

In English

Författare

  • Yasushi Suwazono
  • Salomon Sand
  • Marie Vahter
  • Agneta Falk Filipsson
  • Staffan Skerfving
  • Jonas Lidfeldt
  • Agneta Akesson

Summary, in English

OBJECTIVES: Our goal in this study was to explore the use of a hybrid approach to calculate benchmark doses (BMDs) and their 95% lower confidence bounds (BMDLs) for renal effects of cadmium in a population with low environmental exposure. METHODS: Morning urine and blood samples were collected from 820 Swedish women 53-64 years of age. We measured urinary cadmium (U-Cd) and tubular effect markers [N-acetyl-beta-D-glucosaminidase (NAG) and human complex-forming protein (protein HQ in 790 women and estimated glomerular filtration rate (GFR; based on serum cystatin Q in 700 women. Age, body mass index, use of nonsteroidal anti-inflammatory drugs, and blood lead levels were used as covariates for estimated GFR. BMDs/BMDLs corresponding to an additional risk (benchmark response) of 5 or 10% were calculated (the background risk at zero exposure was set to 5%). The results were compared with the estimated critical concentrations obtained by applying logistic models used in previous studies on the present data. RESULTS: For both NAG and protein HC, the BMDs (BMDLs) of U-Cd were 0.5-1.1 (0.4-0.8) mu g/L (adjusted for specific gravity of 1.015 g/mL) and 0.6-1.1 (0.5-0.8) mu g/g creatinine. For estimated GFR, the BMDs (BMDLs) were 0.8-1.3 (0.5-0.9) mu g/L adjusted for specific gravity and 1.1-1.8 (0.7-1.2) mu g/g creatinine. CONCLUSION: The obtained benchmark doses of U-Cd were lower than the critical concentrations previously reported. The critical dose level for glomerular effects was only slightly higher than that for tubular effects. We suggest that the hybrid approach is more appropriate for estimation of the critical U-Cd concentration, because the choice of cutoff values in logistic models largely influenced the obtained critical U-Cd.

Publiceringsår

2006

Språk

Engelska

Sidor

1072-1076

Publikation/Tidskrift/Serie

Environmental Health Perspectives

Volym

114

Issue

7

Dokumenttyp

Artikel i tidskrift

Förlag

National Institute of Environmental Health Sciences

Ämne

  • Environmental Health and Occupational Health

Nyckelord

  • renal tubular dysfunction
  • glomerular dysfunction
  • renal
  • human
  • environmental exposure
  • benchmark dose
  • continuous data
  • urinary cadmium
  • risk assessment

Status

Published

Forskningsgrupp

  • Family Medicine and Community Medicine

ISBN/ISSN/Övrigt

  • ISSN: 1552-9924