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The effect of dietary administration of 2-oxoglutaric acid on the cartilage and bone of growing rats

In English

Författare

Summary, in English

2-Oxoglutaric acid (2-Ox), a precursor to hydroxyproline - the most abundant amino acid in bone collagen, exerts protective effects on bone development during different stages of organism development; however, little is known about the action of 2-Ox on cartilage. The aim of the present study was to elucidate the influence of dietary 2-Ox supplementation on the growth plate, articular cartilage and bone of growing rats. A total of twelve male Sprague-Dawley rats were used in the study. Half of the rats received 2-oxoglutarate at a dose of 0.75 g/kg body weight per d in their drinking-water. Body and organ weights were measured. Histomorphometric analyses of the cartilage and bone tissue of the femora and tibiae were conducted, as well as bone densitometry and peripheral quantitative computed tomography (pQCT). Rats receiving 2-Ox had an increased body mass (P<0.001) and absolute liver weight (P=0.031). Femoral length (P=0.045) and bone mineral density (P=0.014), overall thickness of growth plate (femur P=0.036 and tibia P=0.026) and the thickness of femoral articular cartilage (P<0.001) were also increased. 2-Ox administration had no effect on the mechanical properties or on any of the measured pQCT parameters for both bones analysed. There were also no significant differences in histomorphometric parameters of tibial articular cartilage and autofluorescence of femoral and tibial growth plate cartilage. Dietary supplementation with 2-Ox to growing rats exerts its effects mainly on cartilage tissue, having only a slight influence on bone. The effect of 2-Ox administration was selective, depending on the particular bone and type of cartilage analysed.

Publiceringsår

2013

Språk

Engelska

Sidor

651-658

Publikation/Tidskrift/Serie

British Journal of Nutrition

Volym

110

Issue

4

Dokumenttyp

Artikel i tidskrift

Förlag

Cambridge University Press

Ämne

  • Nutrition and Dietetics

Nyckelord

  • 2-Oxoglutaric acid
  • Bone
  • Growth plate
  • Articular cartilage
  • Growing
  • rats

Status

Published

ISBN/ISSN/Övrigt

  • ISSN: 1475-2662