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Lymphomyeloid Contribution of an Immune-Restricted Progenitor Emerging Prior to Definitive Hematopoietic Stem Cells.

In English

Författare

  • Charlotta Böiers
  • Joana Carrelha
  • Michael Lutteropp
  • Sidinh Luc
  • Joanna C A Green
  • Emanuele Azzoni
  • Petter S Woll
  • Adam J Mead
  • Anne Hultquist
  • Gemma Swiers
  • Elisa Gomez Perdiguero
  • Iain C Macaulay
  • Luca Melchiori
  • Tiago C Luis
  • Shabnam Kharazi
  • Tiphaine Bouriez-Jones
  • Qiaolin Deng
  • Annica Pontén
  • Deborah Atkinson
  • Christina Jensen
  • Ewa Sitnicka Quinn
  • Frederic Geissmann
  • Isabelle Godin
  • Rickard Sandberg
  • Marella F T R de Bruijn
  • Sten Eirik W Jacobsen
Visa allt

Summary, in English

In jawed vertebrates, development of an adaptive immune-system is essential for protection of the born organism against otherwise life-threatening pathogens. Myeloid cells of the innate immune system are formed early in development, whereas lymphopoiesis has been suggested to initiate much later, following emergence of definitive hematopoietic stem cells (HSCs). Herein, we demonstrate that the embryonic lymphoid commitment process initiates earlier than previously appreciated, prior to emergence of definitive HSCs, through establishment of a previously unrecognized entirely immune-restricted and lymphoid-primed progenitor. Notably, this immune-restricted progenitor appears to first emerge in the yolk sac and contributes physiologically to the establishment of lymphoid and some myeloid components of the immune-system, establishing the lymphomyeloid lineage restriction process as an early and physiologically important lineage-commitment step in mammalian hematopoiesis.

Publiceringsår

2013

Språk

Engelska

Sidor

535-548

Publikation/Tidskrift/Serie

Cell Stem Cell

Volym

13

Issue

5

Dokumenttyp

Artikel i tidskrift

Förlag

Cell Press

Ämne

  • Cell Biology

Status

Published

Forskningsgrupp

  • Developmental lymphopoiesis and leukemia

ISBN/ISSN/Övrigt

  • ISSN: 1934-5909