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Cadmium-induced effects on bone in a population-based study of women

In English

Författare

Summary, in English

High cadmium exposure is known to cause bone damage, but the association between low-level cadmium exposure and osteoporosis remains to be clarified. Using a population-based women's health survey in southern Sweden [Women's Health in the Lund Area (WHILA)] with no known historical cadmium contamination, we investigated cadmium-related effects on bone in 820 women (53-64 years of age). We measured cadmium in blood and urine and lead in blood, an array of markers of bone metabolism, and forearm bone mineral density (BMD). Associations were evaluated in multiple linear regression analysis including information on the possible confounders or effect modifiers: weight, menopausal status, use of hormone replacement therapy, age at menarche, alcohol consumption, smoking history, and physical activity. Median urinary cadmium was 0.52 mu g/L adjusted to density (0.67 mu g/g creatinine). After multivariate adjustment, BMD, parathyroid hormone, and urinary deoxypyridinoline (U-DPD) were adversely associated with concentrations of urinary cadmium (p < 0.05) in all subjects. These associations persisted in the group of never-smokers, which had the lowest cadmium exposure (mainly dietary). For U-DPD, there was a significant interaction between cadmium and menopause (p = 0.022). Our results suggest negative effects of low-level cadmium exposure on bone, possibly exerted via increased bone resorption, which seemed to be intensified after menopause. Based on the prevalence of osteoporosis and the low level of exposure, the observed effects, although slight, should be considered as early signals of potentially more adverse health effects.

Publiceringsår

2006

Språk

Engelska

Sidor

830-834

Publikation/Tidskrift/Serie

Environmental Health Perspectives

Volym

114

Issue

6

Dokumenttyp

Artikel i tidskrift

Förlag

National Institute of Environmental Health Sciences

Ämne

  • Environmental Health and Occupational Health

Nyckelord

  • women
  • bone mineral density
  • osteoporosis
  • biochemical bone markers
  • lead
  • cadmium

Status

Published

Forskningsgrupp

  • Family Medicine and Community Medicine

ISBN/ISSN/Övrigt

  • ISSN: 1552-9924